Author: Bohmwald, Karen; Gálvez, Nicolás M. S.; Ríos, Mariana; Kalergis, Alexis M.
Title: Neurologic Alterations Due to Respiratory Virus Infections Document date: 2018_10_26
ID: 0rlotyz3_44
Snippet: HCoV capacity to reach CNS after the nasal infection has been described previously in mice, particularly for HCoV-OC43 (St-Jean et al., 2004) . St-Jean et al. (2004) reported that upon infection, viral antigens are detected in the olfactory bulb 3 days later, with no presence of virus in perivascular blood cells or any other part of the brain. After 7 days, the virus is detected throughout the whole brain tissue, indicating that it can rapidly pr.....
Document: HCoV capacity to reach CNS after the nasal infection has been described previously in mice, particularly for HCoV-OC43 (St-Jean et al., 2004) . St-Jean et al. (2004) reported that upon infection, viral antigens are detected in the olfactory bulb 3 days later, with no presence of virus in perivascular blood cells or any other part of the brain. After 7 days, the virus is detected throughout the whole brain tissue, indicating that it can rapidly propagate once set in CNS. This replication leads to a rapid death by acute encephalitis of infected mice. Remarkably, ablation of the olfactory bulb prevented the spread of mouse hepatitis virus (MHV), upon nasal infection (Perlman et al., 1990) . Therefore, HCoV exhibits an intrinsic capability to infect neural cells and spread from CNS to the periphery via a transneural route, as has also been seen for MHV (Perlman et al., 1990; Barthold et al., 1990 ; Figure 3) .
Search related documents:
Co phrase search for related documents- acute encephalitis and brain tissue: 1, 2, 3, 4, 5, 6, 7, 8, 9
- acute encephalitis and CNS spread: 1
- acute encephalitis and hepatitis virus: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37
- acute encephalitis and infected mouse: 1, 2, 3, 4, 5, 6
- acute encephalitis and MHV mouse hepatitis virus: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18
- acute encephalitis and mouse hepatitis virus: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26
- acute encephalitis and nasal infection: 1
- acute encephalitis and olfactory bulb: 1, 2, 3, 4
- acute encephalitis and previously describe: 1
- acute encephalitis and viral antigen: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
- acute encephalitis and virus presence: 1, 2, 3, 4, 5, 6, 7, 8
- blood cell and brain tissue: 1, 2, 3, 4, 5, 6, 7
- blood cell and hepatitis virus: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
- blood cell and infected mouse: 1, 2
- blood cell and MHV mouse hepatitis virus: 1, 2, 3, 4
- blood cell and mouse hepatitis virus: 1, 2, 3, 4, 5
- blood cell and nasal infection: 1
- blood cell and neural cell: 1, 2
- blood cell and rapid death: 1, 2
Co phrase search for related documents, hyperlinks ordered by date