Author: Qingyang Xu; Shomesh Chaudhuri; Danying Xiao; Andrew W Lo
Title: Bayesian Adaptive Clinical Trials for Anti-Infective Therapeutics during Epidemic Outbreaks Document date: 2020_4_14
ID: 20hk99h4_70
Snippet: One interesting trade-off to be explored is the difference between COVID-19 vaccine and an anti-viral treatment that can cure an infected patient. While prevention through vaccination is the ultimate solution, a successful treatment for the disease using repurposed drugs that have already been approved for other indications (and whose safety profile has already been established) may be even more valuable, especially if it can be deployed in the n.....
Document: One interesting trade-off to be explored is the difference between COVID-19 vaccine and an anti-viral treatment that can cure an infected patient. While prevention through vaccination is the ultimate solution, a successful treatment for the disease using repurposed drugs that have already been approved for other indications (and whose safety profile has already been established) may be even more valuable, especially if it can be deployed in the nearer term and reduce the growing fear and panic among the general population. In such cases, the approval threshold should clearly reflect these cost/benefit differences.
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