Author: Wysocki, Jan; Schulze, Arndt; Batlle, Daniel
Title: Novel Variants of Angiotensin Converting Enzyme-2 of Shorter Molecular Size to Target the Kidney Renin Angiotensin System Document date: 2019_12_17
ID: 0vozochc_28
Snippet: In fact, for the rACE2 1-619, it was four-fold and for rACE2 1-605 three-fold higher as compared to enzymatic activity of the native rACE2 1-740 ( Figure 5A ). Using Ang II, the natural substrate of ACE2, catalytic efficiencies [K cat /K m (M −1 s −1 )] were found to be not different for native rACE2 1-740 (1.97 × 10 6 ) and for the two shorter proteins rACE2 1-619 (1.02 × 10 6 ) and rACE2 1-605 (1.22 × 10 6 ) ( Figure 5B ) (n = 3-4 experi.....
Document: In fact, for the rACE2 1-619, it was four-fold and for rACE2 1-605 three-fold higher as compared to enzymatic activity of the native rACE2 1-740 ( Figure 5A ). Using Ang II, the natural substrate of ACE2, catalytic efficiencies [K cat /K m (M −1 s −1 )] were found to be not different for native rACE2 1-740 (1.97 × 10 6 ) and for the two shorter proteins rACE2 1-619 (1.02 × 10 6 ) and rACE2 1-605 (1.22 × 10 6 ) ( Figure 5B ) (n = 3-4 experiments for each protein).
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