Passive immunization does not provide protection against experimental infection with Mycoplasma haemofelis

Sugiarto, Sarah; Spiri, Andrea M.; Riond, Barbara; Novacco, Marilisa; Oestmann, Angelina; de Miranda, Luisa H. Monteiro; Meli, Marina L.; Boretti, Felicitas S.; Hofmann-Lehmann, Regina; Willi, Barbara

Up to 22 different parameters per cat were statistically analyzed using Analyse-it ® for Microsoft Excel version 1.0.5.0 (Analyse-it Software, Ltd., Leeds, UK) and Graph-Pad Prism 5.03 (GraphPad Software, Inc., CA, USA). The Mann-Whitney U test (p MWU ) was used to compare the two groups A and B at each time point. One cat (JHW3) in group B stayed PCR-negative and seronegative throughout the 100-day study period. To investigate whether significant differences observed between groups A and B were related to the inclusion of this cat, the Mann-Whitney U tests were repeated without the data of this cat for all significant parameters. The results from these analyses were reported if they differed from the original results including cat JHW3. Friedman's test (p F ) followed by Dunn's post test (p D ) was used to analyze the parameters over time when more than two time points were considered. Multiplicity adjusted P values for each comparison in a family of comparisons were computed. Fisher's exact test was used to determine significant differences of proportions. P values <0.05 were considered significant.