Selected article for: "proteolytic cleavage and virus infectivity"
Author: Pan, Yen-Yu; Wang, Shiu-Mei; Huang, Kuo-Jung; Chiang, Chien-Cheng; Wang, Chin-Tien
Title: Placement of Leucine Zipper Motifs at the Carboxyl Terminus of HIV-1 Protease Significantly Reduces Virion Production
  • Document date: 2012_3_1
    • ID: 09locmnw_1
    Snippet: Human immunodeficiency virus type 1 (HIV-1) gag encodes a polypeptide Pr55 gag that can self-assemble into virus-like particles (VLPs) [1] . During or soon after virus release from cells, Pr55 gag is cleaved by viral protease (PR) into four major products: matrix (MA, p17), capsid (CA, p24), nucleocapsid (NC, p7), and p6 domains [1] . PR is encoded by pol, which is initially translated as a Pr160 gag-pol polyprotein by a ribosomal frameshift even.....
    Document: Human immunodeficiency virus type 1 (HIV-1) gag encodes a polypeptide Pr55 gag that can self-assemble into virus-like particles (VLPs) [1] . During or soon after virus release from cells, Pr55 gag is cleaved by viral protease (PR) into four major products: matrix (MA, p17), capsid (CA, p24), nucleocapsid (NC, p7), and p6 domains [1] . PR is encoded by pol, which is initially translated as a Pr160 gag-pol polyprotein by a ribosomal frameshift event that occurs at a frequency of 5%, resulting in the expression of Pr160 gag-pol to Pr55 gag at a ratio of approximately 1:20 [2] . Pr160 gag-pol is incorporated into virions via interactions with assembling Pr55 gag [3, 4, 5, 6, 7, 8] . Pr160 gag-pol cleavage by PR yields reverse transcriptase (RT) and integrase (IN) in addition to Gag products. The PRmediated proteolytic cleavage of Pr55 gag and Pr160 gag-pol , known as virus maturation, is essential for the acquisition of viral infectivity [9, 10, 11, 12, 13] .

    Search related documents:
    Co phrase search for related documents
    • cell virus release and human immunodeficiency: 1, 2
    • cell virus release and proteolytic cleavage: 1
    • cell virus release and viral infectivity: 1
    • frameshift event and gag pol: 1, 2, 3, 4, 5
    • frameshift event and gag product: 1
    • frameshift event and human immunodeficiency: 1, 2, 3
    • frameshift event and reverse transcriptase: 1
    • frameshift event and viral infectivity: 1, 2
    • gag pol and human immunodeficiency: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • gag pol and reverse transcriptase: 1, 2, 3, 4, 5, 6, 7, 8, 9
    • gag pol and viral infectivity: 1, 2, 3, 4
    • gag pol cleavage and human immunodeficiency: 1
    • gag pol cleavage and reverse transcriptase: 1
    • gag product and human immunodeficiency: 1
    • gag product and proteolytic cleavage: 1
    • human immunodeficiency and PR viral protease: 1
    • human immunodeficiency and proteolytic cleavage: 1, 2
    • human immunodeficiency and reverse transcriptase: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • human immunodeficiency and viral infectivity: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18