Author: Brisse, Morgan; Ly, Hinh
Title: Comparative Structure and Function Analysis of the RIG-I-Like Receptors: RIG-I and MDA5 Document date: 2019_7_17
ID: 1enteev7_40
Snippet: The preference for specific RNA species by RIG-I and MDA5 allow for them to distinguish between viral RNA and host RNA in most circumstances (225) , although the specific mechanisms of distinction are not as clear for MDA5 as for RIG-I. Studies from clinical cases of MDA5 mutations provide contradictory models, with certain mutations found in Aicardi-Goutières syndrome (AGS) increasing MDA5 avidity for self RNA (226) with Alu retroelements found.....
Document: The preference for specific RNA species by RIG-I and MDA5 allow for them to distinguish between viral RNA and host RNA in most circumstances (225) , although the specific mechanisms of distinction are not as clear for MDA5 as for RIG-I. Studies from clinical cases of MDA5 mutations provide contradictory models, with certain mutations found in Aicardi-Goutières syndrome (AGS) increasing MDA5 avidity for self RNA (226) with Alu retroelements found to be significantly enriched for interaction with AGS MDA5 mutations (227) . The modification of dsRNA by host cells may be a primary inhibitor of MDA5 activation by host RNA as knockout of adenosine deaminase (ADAR1), which weakens dsRNA structures, allows wild-type MDA5 to be activated by Alu retroelements (227) . However, other MDA5 mutations decrease affinity for known MDA5 ligands and ATPase activity, yet still demonstrate increased IFNβ expression (228, 229) .
Search related documents:
Co phrase search for related documents- Aicardi Goutières syndrome and host rna: 1
- ATPase activity and host rna: 1, 2, 3, 4
- ATPase activity and IFNβ expression: 1
- certain mutation and host cell: 1
- clinical case and host cell: 1, 2
- clinical case and host rna: 1
- clinical case and increase IFNβ expression: 1
- dsRNA structure and host rna: 1
- host cell and IFNβ expression: 1, 2, 3, 4
- host rna and IFNβ expression: 1
- IFNβ expression and increase IFNβ expression: 1, 2, 3
Co phrase search for related documents, hyperlinks ordered by date