Author: Zhao, Bing; Chen, Ye-Guang
Title: Regulation of TGF-ß Signal Transduction Document date: 2014_9_23
ID: 1ag9mnd2_10
Snippet: Previous studies associated the deviant expression of PICK1 in brain with mental disorders such as schizophrenia [58] [59] [60] . However, PICK1 is ubiquitously expressed in many organs outside the nervous system, and its physiological functions have not been fully investigated. By modulating the signaling, PICK1 may participate in TGF--related processes. Indeed, we observed a significant negative correlation between PICK1 expression and T RI or .....
Document: Previous studies associated the deviant expression of PICK1 in brain with mental disorders such as schizophrenia [58] [59] [60] . However, PICK1 is ubiquitously expressed in many organs outside the nervous system, and its physiological functions have not been fully investigated. By modulating the signaling, PICK1 may participate in TGF--related processes. Indeed, we observed a significant negative correlation between PICK1 expression and T RI or phospho-Smad2 levels in human breast tumors, indicating that PICK1 may be involved in breast cancer development through inhibition of TGF-signaling [51] . This idea is also supported by other reports suggesting that PICK1 is associated with human cancer development [57, [61] [62] [63] .
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