Selected article for: "cell growth and differential expression"
Author: Stepanov, Grigory A.; Filippova, Julia A.; Komissarov, Andrey B.; Kuligina, Elena V.; Richter, Vladimir A.; Semenov, Dmitry V.
Title: Regulatory Role of Small Nucleolar RNAs in Human Diseases
  • Document date: 2015_4_28
    • ID: 0ws5q37g_32
    Snippet: Vast majority of noncoding RNAs are subjected to differential regulation in response to virus infection, yet the examples of changes in expression of snoRNAs in infected cells are very limited. Recently, the analysis of lung transcriptome in mice infected with SARS-CoV or influenza A virus has revealed differential expression of 30 small RNAs overlapping with annotated snoRNAs. Two putative snoR-NAs differentially regulated by respiratory virus i.....
    Document: Vast majority of noncoding RNAs are subjected to differential regulation in response to virus infection, yet the examples of changes in expression of snoRNAs in infected cells are very limited. Recently, the analysis of lung transcriptome in mice infected with SARS-CoV or influenza A virus has revealed differential expression of 30 small RNAs overlapping with annotated snoRNAs. Two putative snoR-NAs differentially regulated by respiratory virus infection were found in GAS5 locus [84] . Intriguing, GAS5 intronic snoRNAs U44, U76, and U78 were found to be upregulated in human cells infected with chikungunya virus [79] . It can be speculated that GAS5 intronic snoRNAs may be involved in the regulation of T-cell growth [85] .

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