Selected article for: "expression level and snorna expression level"
Author: Stepanov, Grigory A.; Filippova, Julia A.; Komissarov, Andrey B.; Kuligina, Elena V.; Richter, Vladimir A.; Semenov, Dmitry V.
Title: Regulatory Role of Small Nucleolar RNAs in Human Diseases
  • Document date: 2015_4_28
    • ID: 0ws5q37g_9
    Snippet: The defects in ribosome maturation and function can cause disruption of vital processes and lead to diseases and transformation of normal cells into tumor cells [32] [33] [34] . Since snoRNAs are involved in the regulation of posttranscriptional modification of ribosomal RNAs, it is fair to assume that snoRNA level can affect physiological condition of cells, tissues, and organs. Thus, the change in snoRNA expression level may lead to various dis.....
    Document: The defects in ribosome maturation and function can cause disruption of vital processes and lead to diseases and transformation of normal cells into tumor cells [32] [33] [34] . Since snoRNAs are involved in the regulation of posttranscriptional modification of ribosomal RNAs, it is fair to assume that snoRNA level can affect physiological condition of cells, tissues, and organs. Thus, the change in snoRNA expression level may lead to various diseases. Hence, the studies aimed at evaluating snoRNA expression levels in human and mammalian cells might underpin the development of diagnostic approaches and generation of novel therapeutic agents.

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