Selected article for: "genetic system and reverse genetic system"

Author: Schwarz, Megan C.; Sourisseau, Marion; Espino, Michael M.; Gray, Essanna S.; Chambers, Matthew T.; Tortorella, Domenico; Evans, Matthew J.
Title: Rescue of the 1947 Zika Virus Prototype Strain with a Cytomegalovirus Promoter-Driven cDNA Clone
  • Document date: 2016_9_28
  • ID: 0i1abjfa_2
    Snippet: ZIKV was first identified nearly 70 years ago (2) and has been progressively circulating in various parts of the world, including Africa and Asia. ZIKV emergence in South America in the last 2 years marked the first observation of a link between infections and severe forms of pathogenesis, including microcephaly and Guillain-Barré syndrome (3) . It is not known if the diseases caused by recent infections are a result of changes to the virus that.....
    Document: ZIKV was first identified nearly 70 years ago (2) and has been progressively circulating in various parts of the world, including Africa and Asia. ZIKV emergence in South America in the last 2 years marked the first observation of a link between infections and severe forms of pathogenesis, including microcephaly and Guillain-Barré syndrome (3) . It is not known if the diseases caused by recent infections are a result of changes to the virus that increase pathogenesis or are influenced by host polymorphisms and immune reactions. The African, Asian, and South American ZIKV isolates are closely related phylogenetically; the original 1947 strain, termed MR766 (accession no. HQ234498) (2) , and a recent isolate identified in Puerto Rico, termed PRV2015 (accession no. KU501215) (4), share 96.9% amino acid identity. Thus, the characterization of sequence changes between these isolates that impact replication and disease should be reasonably straightforward. Such studies would be greatly empowered by the availability of a simple system to assay the functional consequences of altering viral sequences (i.e., a "reverse genetic" system).

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