Author: Zhao, Huabin; Ru, Binghua; Teeling, Emma C.; Faulkes, Christopher G.; Zhang, Shuyi; Rossiter, Stephen J.
Title: Rhodopsin Molecular Evolution in Mammals Inhabiting Low Light Environments Document date: 2009_12_16
ID: 02uqygfs_2
Snippet: Light sensitive pigments comprise a membrane bound Gprotein-coupled receptor (GPCR) known as an opsin and a chromophore group (typically 11-cis retinal in mammals) [10] . Absorption of light results in photoisomerisation of the chromophore, which induces conformation changes in the opsin that leads to signal transduction. Most mammals possess three classes of opsins, which differ in their absorption spectra. The SWS1 (short-wavelength sensitive t.....
Document: Light sensitive pigments comprise a membrane bound Gprotein-coupled receptor (GPCR) known as an opsin and a chromophore group (typically 11-cis retinal in mammals) [10] . Absorption of light results in photoisomerisation of the chromophore, which induces conformation changes in the opsin that leads to signal transduction. Most mammals possess three classes of opsins, which differ in their absorption spectra. The SWS1 (short-wavelength sensitive type 1) and M/LWS (middle/long-wavelength sensitive) are restricted to cone photoreceptor cells and are typically responsible for color vision in bright light [8, 11] , whereas rhodopsin occurs on the rod cells and is extremely sensitive, so enabling dim light (scotopic) vision [8, 9] .
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