Author: Liu, Weiwei; Ding, Chan
Title: Roles of LncRNAs in Viral Infections Document date: 2017_5_26
ID: 02zv1gsq_30
Snippet: Herpesvirus saimiri, which causes aggressive T-cell leukemia and lymphoma, encodes 7 HSURs (Herpesvirus saimiri (HVS) U-rich RNAs) (Lee et al., 1988; Wassarman et al., 1989; Albrecht and Fleckenstein, 1992) . The expression of host genes linked to T cell activation in virally transformed T cells was up regulated by HSURs 1 and 2 (Cook et al., 2005) . HSUR 1 directs degradation of host mature miR-27 in a sequence-specific and bindingdependent mann.....
Document: Herpesvirus saimiri, which causes aggressive T-cell leukemia and lymphoma, encodes 7 HSURs (Herpesvirus saimiri (HVS) U-rich RNAs) (Lee et al., 1988; Wassarman et al., 1989; Albrecht and Fleckenstein, 1992) . The expression of host genes linked to T cell activation in virally transformed T cells was up regulated by HSURs 1 and 2 (Cook et al., 2005) . HSUR 1 directs degradation of host mature miR-27 in a sequence-specific and bindingdependent manner in virally transformed T cells , illustrating a ncRNA to manipulate host-cell gene expression via the miRNA pathway after viral infection.
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