Selected article for: "RNA synthesis and viral rna"
Author: Sun, Di; Chen, Shun; Cheng, Anchun; Wang, Mingshu
Title: Roles of the Picornaviral 3C Proteinase in the Viral Life Cycle and Host Cells
  • Document date: 2016_3_17
    • ID: 07nfb69o_59
    Snippet: Due to their proteinase activities, 3C pro and its precursor 3CD are involved in the processing of the polyprotein, but their catalytic efficiencies and specificities exhibit differences that are related to the different substrate-binding site residues in the 3C domain and the N-terminus of 3C pro . The RNA-binding activity of 3C pro is important for initiating viral RNA synthesis. 3C pro and its 3ABC, 3BC, 3BCD and P3 precursors can stimulate RN.....
    Document: Due to their proteinase activities, 3C pro and its precursor 3CD are involved in the processing of the polyprotein, but their catalytic efficiencies and specificities exhibit differences that are related to the different substrate-binding site residues in the 3C domain and the N-terminus of 3C pro . The RNA-binding activity of 3C pro is important for initiating viral RNA synthesis. 3C pro and its 3ABC, 3BC, 3BCD and P3 precursors can stimulate RNA synthesis at different levels. Due to the limited encoding capacity of picornaviruses, essential functions are performed by modulation of 3C pro and its precursors.

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