Author: Shen, Zu T.; Sigalov, Alexander B.
Title: SARS Coronavirus Fusion Peptide-Derived Sequence Suppresses Collagen-Induced Arthritis in DBA/1J Mice Document date: 2016_6_28
ID: 10wcqgaq_5
Snippet: To evaluate a putative anti-arthritic activity of SARS-CoV FP, we used the SARS-CoV FP-derived peptide sequence MWKTPTLKYFG (MG11). This peptide includes the charge distribution pattern with two essential positively charged amino acid residues (underlined) spaced apart by four amino acids that is similar to that of the TCRα chain TMD either of human (VIGFRILLLKVAGFNLLMTL) or mouse (SVMGLRILLLKVAGFNLLMTL) origin. Based on the SCHOOL model, this s.....
Document: To evaluate a putative anti-arthritic activity of SARS-CoV FP, we used the SARS-CoV FP-derived peptide sequence MWKTPTLKYFG (MG11). This peptide includes the charge distribution pattern with two essential positively charged amino acid residues (underlined) spaced apart by four amino acids that is similar to that of the TCRα chain TMD either of human (VIGFRILLLKVAGFNLLMTL) or mouse (SVMGLRILLLKVAGFNLLMTL) origin. Based on the SCHOOL model, this sequence has been previously hypothesized to have a similar immunomodulatory activity as TCR CP (GLRILLLKV) or HIV gp41 FP 29 . A SARS CoV FP peptide mutant with two functionally important lysines replaced by glycines (MG11-2G) was used as a negative control peptide. We used the CIA mouse model, the most commonly studied autoimmune model of rheumatoid arthritis (RA) 30 , since a vast majority of the studies of immunomodulatory activity of TCR CP and HIV gp41 FP has been done in animal models of autoimmune arthritis 18, 20, 22, 23, 31, 32 .
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