Author: Frieman, Matthew B.; Chen, Jun; Morrison, Thomas E.; Whitmore, Alan; Funkhouser, William; Ward, Jerrold M.; Lamirande, Elaine W.; Roberts, Anjeanette; Heise, Mark; Subbarao, Kanta; Baric, Ralph S.
Title: SARS-CoV Pathogenesis Is Regulated by a STAT1 Dependent but a Type I, II and III Interferon Receptor Independent Mechanism Document date: 2010_4_8
ID: 15rtwl26_1
Snippet: SARS Coronavirus (SARS-CoV) is a highly pathogenic respiratory virus that emerged in China during the winter of 2002 and infected about 8,000 people globally and resulted in ,800 deaths, with greatly increased mortality rates in persons over 50 years of age (WHO). On initial isolation of SARS-CoV from infected patients, it was identified as a novel Group 2 Coronavirus and the genetic mechanisms governing the increased pathogenicity of the virus r.....
Document: SARS Coronavirus (SARS-CoV) is a highly pathogenic respiratory virus that emerged in China during the winter of 2002 and infected about 8,000 people globally and resulted in ,800 deaths, with greatly increased mortality rates in persons over 50 years of age (WHO). On initial isolation of SARS-CoV from infected patients, it was identified as a novel Group 2 Coronavirus and the genetic mechanisms governing the increased pathogenicity of the virus remain undefined [1, 2] . In severe cases, SARS-CoV infection rapidly progressed to acute respiratory distress syndrome (ARDS) during the acute phase of infection or to an organizing phase diffuse alveolar damage following virus clearance; two clinically devastating end stage lung diseases. The molecular mechanisms governing these severe end stage lung disease outcomes are unknown, although similar pathologies have been reported following H5N1 and 1918 influenza virus infection.
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