Author: Frieman, Matthew B.; Chen, Jun; Morrison, Thomas E.; Whitmore, Alan; Funkhouser, William; Ward, Jerrold M.; Lamirande, Elaine W.; Roberts, Anjeanette; Heise, Mark; Subbarao, Kanta; Baric, Ralph S.
Title: SARS-CoV Pathogenesis Is Regulated by a STAT1 Dependent but a Type I, II and III Interferon Receptor Independent Mechanism Document date: 2010_4_8
ID: 15rtwl26_28
Snippet: In Urbani virus infected lungs, minimal changes were seen in 129 WT, IFNAR12/2, IFNAGR2/2 mice for all 4 cytokines ( Figure 4A , B, C and D). However, in STAT1 2/2 mice, significant increases in protein expression patterns were detected across different time points, peaking between 9 and 15 days postinfection. TNFa protein levels increased steadily from day 2 through day 29 post-infection while IL6 and IFNc protein levels peaked at day 9, before .....
Document: In Urbani virus infected lungs, minimal changes were seen in 129 WT, IFNAR12/2, IFNAGR2/2 mice for all 4 cytokines ( Figure 4A , B, C and D). However, in STAT1 2/2 mice, significant increases in protein expression patterns were detected across different time points, peaking between 9 and 15 days postinfection. TNFa protein levels increased steadily from day 2 through day 29 post-infection while IL6 and IFNc protein levels peaked at day 9, before reducing to levels seen in mock infected animals. MCP1 protein levels were increased between days 5 through 22 but diminished by day 29 post-infection.
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