Author: Martinez-Martin, Nadia
Title: Technologies for Proteome-Wide Discovery of Extracellular Host-Pathogen Interactions Document date: 2017_2_22
ID: 1giy1fow_46
Snippet: Altogether, these studies elegantly demonstrate the power of genome-wide screens in human haploid cells and the power of this approach to study virus-host interactions. Future studies should further assess the applicability of this method for general detection of interactions that take place at the pathogen-plasma membrane interface. It will also be important to generate additional haploid cell lines, in order to broaden the range of pathogens an.....
Document: Altogether, these studies elegantly demonstrate the power of genome-wide screens in human haploid cells and the power of this approach to study virus-host interactions. Future studies should further assess the applicability of this method for general detection of interactions that take place at the pathogen-plasma membrane interface. It will also be important to generate additional haploid cell lines, in order to broaden the range of pathogens and pathogen-derived molecules that can be studied using these genetic tools. In this regard, a number of haploid cell lines have been generated in mammals [137] , unique tools to elucidate the basic aspects of human genetics.
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