Author: Lien, Gi-Shih; Liu, Jen-Fang; Chien, Ming-Hsien; Hsu, Wei-Tse; Chang, Tzu-Hao; Ku, Chia-Chi; Ji, Andrea Tung-Qian; Tan, Peng; Hsieh, Ting-Lieh; Lee, Liang-Ming; Ho, Jennifer H
Title: The ability to suppress macrophage-mediated inflammation in orbital fat stem cells is controlled by miR-671-5p Document date: 2014_8_13
ID: 1i6hni9s_3
Snippet: Little is known about the effect of MSCs on macrophages, critical players of the innate immune response involved in almost all immune-mediated diseases. Only a few studies report that MSCs derived from bone marrow or gingiva promote the generation of regulatory macrophages (M2) [17] [18] [19] [20] . Interleukin-1 receptor antagonist (IL-1RA) produced by MSCs serves as a key factor for inhibiting macrophage-mediated inflammation in acute lung inju.....
Document: Little is known about the effect of MSCs on macrophages, critical players of the innate immune response involved in almost all immune-mediated diseases. Only a few studies report that MSCs derived from bone marrow or gingiva promote the generation of regulatory macrophages (M2) [17] [18] [19] [20] . Interleukin-1 receptor antagonist (IL-1RA) produced by MSCs serves as a key factor for inhibiting macrophage-mediated inflammation in acute lung injury (ALI) [21] . Our previous work demonstrates that orbital fat-derived stem cells (OFSCs), MSCs isolated from human orbital fat tissues [22] , are effective in modulating lipopolysaccharide (LPS)-induced acute lung inflammation [23] . The therapeutic effect of OFSCs in vivo is attributed to inhibition of macrophage-mediated inflammatory response, and the paracrine effect of OFSCs contributes the major therapeutic benefit. However, the circulation cytokine profile altered by OFSCs is not identical to that altered by bone marrow-derived MSCs in mice with ALI.
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