Selected article for: "CRP analysis and detection limit"
Author: ten Oever, Jaap; Kox, Matthijs; van de Veerdonk, Frank L; Mothapo, Khutso M; Slavcovici, Adriana; Jansen, Tim L; Tweehuysen, Lieke; Giamarellos-Bourboulis, Evangelos J; Schneeberger, Peter M; Wever, Peter C; Stoffels, Monique; Simon, Anna; van der Meer, Jos WM; Johnson, Melissa D; Kullberg, Bart-Jan; Pickkers, Peter; Pachot, Alexandre; Joosten, Leo AB; Netea, Mihai G
Title: The discriminative capacity of soluble Toll-like receptor (sTLR)2 and sTLR4 in inflammatory diseases
  • Document date: 2014_11_19
    • ID: 0zkeoa1z_23
    Snippet: CRP levels showed good value to discriminate between bacterial and viral infections with an AUC of 0.94 (95% CI 0.90-0.96). sTLR4 levels displayed a significantly lower AUC compared with CRP: 0.75 (95% CI 0.70-0.82), P < 0.0001. sTLR2 was a poor discriminator between patients with a bacterial or viral infection (Table 4, Figure 5 ). Panel analysis with two biomarkers was comparable to the performance of CRP alone. The cut-off values for the Figur.....
    Document: CRP levels showed good value to discriminate between bacterial and viral infections with an AUC of 0.94 (95% CI 0.90-0.96). sTLR4 levels displayed a significantly lower AUC compared with CRP: 0.75 (95% CI 0.70-0.82), P < 0.0001. sTLR2 was a poor discriminator between patients with a bacterial or viral infection (Table 4, Figure 5 ). Panel analysis with two biomarkers was comparable to the performance of CRP alone. The cut-off values for the Figure 1 Release of IL-6, sTLR2 and sTLR4 after stimulation for 24 hours of peripheral blood mononuclear cells with either medium (control) several microbial stimuli. Data are expressed as means ± SEM (n = 6). The concentrations of IL-6, sTLR2 and sTLR4 after incubation with medium are below the detection limit.

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