Author: ten Oever, Jaap; Kox, Matthijs; van de Veerdonk, Frank L; Mothapo, Khutso M; Slavcovici, Adriana; Jansen, Tim L; Tweehuysen, Lieke; Giamarellos-Bourboulis, Evangelos J; Schneeberger, Peter M; Wever, Peter C; Stoffels, Monique; Simon, Anna; van der Meer, Jos WM; Johnson, Melissa D; Kullberg, Bart-Jan; Pickkers, Peter; Pachot, Alexandre; Joosten, Leo AB; Netea, Mihai G
Title: The discriminative capacity of soluble Toll-like receptor (sTLR)2 and sTLR4 in inflammatory diseases Document date: 2014_11_19
ID: 0zkeoa1z_23
Snippet: CRP levels showed good value to discriminate between bacterial and viral infections with an AUC of 0.94 (95% CI 0.90-0.96). sTLR4 levels displayed a significantly lower AUC compared with CRP: 0.75 (95% CI 0.70-0.82), P < 0.0001. sTLR2 was a poor discriminator between patients with a bacterial or viral infection (Table 4, Figure 5 ). Panel analysis with two biomarkers was comparable to the performance of CRP alone. The cut-off values for the Figur.....
Document: CRP levels showed good value to discriminate between bacterial and viral infections with an AUC of 0.94 (95% CI 0.90-0.96). sTLR4 levels displayed a significantly lower AUC compared with CRP: 0.75 (95% CI 0.70-0.82), P < 0.0001. sTLR2 was a poor discriminator between patients with a bacterial or viral infection (Table 4, Figure 5 ). Panel analysis with two biomarkers was comparable to the performance of CRP alone. The cut-off values for the Figure 1 Release of IL-6, sTLR2 and sTLR4 after stimulation for 24 hours of peripheral blood mononuclear cells with either medium (control) several microbial stimuli. Data are expressed as means ± SEM (n = 6). The concentrations of IL-6, sTLR2 and sTLR4 after incubation with medium are below the detection limit.
Search related documents:
Co phrase search for related documents- blood mononuclear and cut value: 1
- blood mononuclear and detection limit: 1, 2
- blood mononuclear and mean express: 1
- blood mononuclear and panel analysis: 1, 2
- blood mononuclear and peripheral blood mononuclear cell: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73
- blood mononuclear and viral bacterial infection: 1
- blood mononuclear cell and mean express: 1
- blood mononuclear cell and panel analysis: 1
- blood mononuclear cell and peripheral blood mononuclear cell: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73
- crp compare and viral bacterial infection: 1
- crp level and cut value: 1, 2, 3
- crp level and good value: 1
- crp level and viral bacterial infection: 1, 2, 3
- CRP performance and detection limit: 1
- CRP performance and viral bacterial infection: 1, 2
- cut value and detection limit: 1, 2, 3, 4, 5, 6
- cut value and good value: 1, 2, 3, 4, 5
- cut value and viral bacterial infection: 1, 2
- detection limit and good value: 1
Co phrase search for related documents, hyperlinks ordered by date