Selected article for: "Ï subtype and κ IFN Î"
Author: Shields, Lauren E.; Jennings, Jordan; Liu, Qinfang; Lee, Jinhwa; Ma, Wenjun; Blecha, Frank; Miller, Laura C.; Sang, Yongming
Title: Cross-Species Genome-Wide Analysis Reveals Molecular and Functional Diversity of the Unconventional Interferon-? Subtype
  • Document date: 2019_6_25
    • ID: 14gcu1se_3
    Snippet: Whereas, subtypes such as IFN-α and IFN-β have been widely studied, the unconventional subtypes have been less investigated. In this study, we have determined IFN gene evolution across 120 animal genomes that are available in current genome resources, and shown evolutionary significance and gene expansion of IFN genes in several representative species of amphibians, bats, and ungulates. Further using the porcine and bovine IFN complexes as a mo.....
    Document: Whereas, subtypes such as IFN-α and IFN-β have been widely studied, the unconventional subtypes have been less investigated. In this study, we have determined IFN gene evolution across 120 animal genomes that are available in current genome resources, and shown evolutionary significance and gene expansion of IFN genes in several representative species of amphibians, bats, and ungulates. Further using the porcine and bovine IFN complexes as a model, we have determined the molecular and functional diversity of the evolving IFN subtypes, particularly the less-studied unconventional IFN-ω subtype, which is an IFN subtype emerging after reptiles and expanding in bats and ungulates (7) (8) (9) (10) (11) (12) (13) (14) (15) .

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