Author: Shields, Lauren E.; Jennings, Jordan; Liu, Qinfang; Lee, Jinhwa; Ma, Wenjun; Blecha, Frank; Miller, Laura C.; Sang, Yongming
Title: Cross-Species Genome-Wide Analysis Reveals Molecular and Functional Diversity of the Unconventional Interferon-? Subtype Document date: 2019_6_25
ID: 14gcu1se_42
Snippet: Anti-proliferative activity underlies anti-tumor mechanism of IFNs (4, 34) . Compared with classical IFN-α1 and IFN-β, porcine IFN-ω1 and -ω5 (at the concentrations > 0.02 ng/ml) displayed higher antiproliferative activity in porcine monocytes. In porcine epithelial cell lines from testes (ST) or kidney (PK-15), IFN-ω5 but not IFN-ω1 exerted similar antiproliferative activity as IFN-α1 and IFN-β at the tested concentrations (Figure 6, to.....
Document: Anti-proliferative activity underlies anti-tumor mechanism of IFNs (4, 34) . Compared with classical IFN-α1 and IFN-β, porcine IFN-ω1 and -ω5 (at the concentrations > 0.02 ng/ml) displayed higher antiproliferative activity in porcine monocytes. In porcine epithelial cell lines from testes (ST) or kidney (PK-15), IFN-ω5 but not IFN-ω1 exerted similar antiproliferative activity as IFN-α1 and IFN-β at the tested concentrations (Figure 6, top panel) . Surprisingly, porcine IFN-ω1 and IFN-ω5 also significantly suppressed the proliferation of mouse cell lines, but actually showed stimulation of cell proliferation in both human and monkey kidney cells (A549 and MARC-145). Collectively, porcine IFN-ω subtype, in particular the high antiviral IFN-ω5 also exerted higher antiproliferative activity in all tested porcine cells and mouse cells, but no activity in tested primate cells.
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