Author: Cooray, Samantha; Jin, Li; Best, Jennifer M
Title: The involvement of survival signaling pathways in rubella-virus induced apoptosis Document date: 2005_1_4
ID: 1i36lsj2_14
Snippet: As Ras-Raf-MEK-ERK signaling is crucial to the regulation of cell growth in many cell lines, inhibition of this pathway often has detrimental effects. A typical dose-response curve can be seen with MEK inhibitor U0126 in RK13 cells, with cell viability completely abolished by 60-72 hours p.i. (Fig. 2) . With the addition of RV, the U0126 curve moved to the right, the effect of the drug was delayed by approximately 12 hours......
Document: As Ras-Raf-MEK-ERK signaling is crucial to the regulation of cell growth in many cell lines, inhibition of this pathway often has detrimental effects. A typical dose-response curve can be seen with MEK inhibitor U0126 in RK13 cells, with cell viability completely abolished by 60-72 hours p.i. (Fig. 2) . With the addition of RV, the U0126 curve moved to the right, the effect of the drug was delayed by approximately 12 hours.
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