Author: van Rijn, Anneloes L.; van Boheemen, Sander; Sidorov, Igor; Carbo, Ellen C.; Pappas, Nikos; Mei, Hailiang; Feltkamp, Mariet; Aanerud, Marianne; Bakke, Per; Claas, Eric C. J.; Eagan, Tomas M.; Hiemstra, Pieter S.; Kroes, Aloys C. M.; de Vries, Jutte J. C.
Title: The respiratory virome and exacerbations in patients with chronic obstructive pulmonary disease Document date: 2019_10_24
ID: 0rupk21u_52
Snippet: The sensitivity, specificity and positive and negative predictive values of mNGS were high: 96%, 100%, 82% and 100%, respectively, when encountering a cut-off of �5normalized reads, with a detection limit of approximately Cq 38. The high negative predictive value implicates the potential of mNGS to exclude the most prevalent viral respiratory infections in one test. The potential to exclude any infectious cause, both viral and bacterial, would .....
Document: The sensitivity, specificity and positive and negative predictive values of mNGS were high: 96%, 100%, 82% and 100%, respectively, when encountering a cut-off of �5normalized reads, with a detection limit of approximately Cq 38. The high negative predictive value implicates the potential of mNGS to exclude the most prevalent viral respiratory infections in one test. The potential to exclude any infectious cause, both viral and bacterial, would have significant consequences for starting and/or continuation of antimicrobial or, at the other end of the spectrum, immune-modulating treatment.
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