Author: Lu, Yujie; Liu, Wenjuan; Zhang, Man; Deng, Yanfang; Jiang, Min; Bai, Gang
Title: The Screening Research of NF-?B Inhibitors from Moutan Cortex Based on Bioactivity-Integrated UPLC-Q/TOF-MS Document date: 2019_3_3
ID: 1ahxau9k_1
Snippet: Inflammation is a multicomponent response to injury, tissue stress, and infection, associated with most diseases, and it can occur in various tissues and organs of the organism [1] . Clinically, there are two main categories of anti-inflammatory drugs: steroidal drugs and non-steroidal anti-inflammatory drugs (NSAIDs). Steroidal drugs generally refer to adrenocortical hormones, which have strong anti-inflammatory effect, but have obvious side eff.....
Document: Inflammation is a multicomponent response to injury, tissue stress, and infection, associated with most diseases, and it can occur in various tissues and organs of the organism [1] . Clinically, there are two main categories of anti-inflammatory drugs: steroidal drugs and non-steroidal anti-inflammatory drugs (NSAIDs). Steroidal drugs generally refer to adrenocortical hormones, which have strong anti-inflammatory effect, but have obvious side effects such as water-sodium retention, puffiness, and osteoporosis [2] . And NSAID is one of the most widely used drugs in the world and are mainly classified into salicylates, propionic acids, indoles, fenamic acids, acetic acids and pyrazolones [3] . However, it has potential cardiovascular and gastrointestinal bleeding risks [4] . Due to the strong toxic and side effects of many synthetic drugs, and because traditional Chinese medicine (TCM) has the advantages of abundant resources, definite therapeutic effectiveness, and fewer side effects, the discovery of novel anti-inflammatory drugs from natural compounds has gradually become a research hotspot [5] .
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