Selected article for: "amplicon vector and immune response"
Author: Meier, Anita F.; Suter, Mark; Schraner, Elisabeth M.; Humbel, Bruno M.; Tobler, Kurt; Ackermann, Mathias; Laimbacher, Andrea S.
Title: Transfer of Anti-Rotavirus Antibodies during Pregnancy and in Milk Following Maternal Vaccination with a Herpes Simplex Virus Type-1 Amplicon Vector
  • Document date: 2017_2_16
    • ID: 09hmet7r_40
    Snippet: It is widely accepted that the B-cell arm of the immune response plays a major role in controlling RV infection. Observations are reported not only from mouse experiments but also from clinical studies in piglets and children [37] [38] [39] . However, the mechanisms by which antibody producing cells precisely act against RV are unclear and therefore extensively discussed in the field. It is important to note that the amplicon vector induced a Th1.....
    Document: It is widely accepted that the B-cell arm of the immune response plays a major role in controlling RV infection. Observations are reported not only from mouse experiments but also from clinical studies in piglets and children [37] [38] [39] . However, the mechanisms by which antibody producing cells precisely act against RV are unclear and therefore extensively discussed in the field. It is important to note that the amplicon vector induced a Th1 type of immune response with an increased level of IgG2a over IgG1 (Tables A4 and A5) believed to be effective for the control of viral infection. This Th1 response might be an indication that our system would be able to induce mucosal IgA in humans.

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