Selected article for: "cryo em and em density"
Author: Yuan, Yuan; Cao, Duanfang; Zhang, Yanfang; Ma, Jun; Qi, Jianxun; Wang, Qihui; Lu, Guangwen; Wu, Ying; Yan, Jinghua; Shi, Yi; Zhang, Xinzheng; Gao, George F.
Title: Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains
  • Document date: 2017_4_10
    • ID: 094lgjnn_20
    Snippet: In summary, the observation of flexible RBD in MERS-CoV and SARS-CoV S proteins has an important implication for the pathogenesis: for these two CoVs, the flexible RBD can readily be approached by the receptors to bind and guarantee virus entry. Our results have provided an important framework to understand | Low resolution cryo-EM structure of the disassociated S1 trimer. (a) Cryo-EM electron density of the overall structure of the disassociated.....
    Document: In summary, the observation of flexible RBD in MERS-CoV and SARS-CoV S proteins has an important implication for the pathogenesis: for these two CoVs, the flexible RBD can readily be approached by the receptors to bind and guarantee virus entry. Our results have provided an important framework to understand | Low resolution cryo-EM structure of the disassociated S1 trimer. (a) Cryo-EM electron density of the overall structure of the disassociated S1 trimer. (b) Ribbon view of the S1 trimer, including NTD, RBD, SD1 and SD2. (c,d) Interaction between S1 protomers. The RBD core subdomain and SD1 form quaternary interactions with the NTD to stabilize the disassociated S1 trimer. the entry mechanisms of MERS-CoV and SARS-CoV, and suggest ways for preventing or controlling future outbreaks of MERS-CoV and SARS-CoV.

    Search related documents:
    Co phrase search for related documents
    • core subdomain and cryo em structure: 1, 2
    • core subdomain and electron density: 1
    • core subdomain and overall structure: 1
    • core subdomain and RBD core subdomain: 1, 2, 3
    • cryo em and electron density: 1, 2, 3, 4, 5, 6
    • cryo em and entry mechanism: 1, 2
    • cryo em and Low resolution: 1, 2, 3, 4, 5
    • cryo em and overall structure: 1, 2, 3, 4, 5
    • cryo em and RBD core subdomain: 1
    • cryo em structure and electron density: 1, 2, 3, 4
    • cryo em structure and Low resolution: 1
    • cryo em structure and overall structure: 1, 2, 3, 4
    • cryo em structure and RBD core subdomain: 1
    • electron density and Low resolution: 1
    • electron density and overall structure: 1, 2
    • important framework and Low resolution: 1
    • important framework provide and Low resolution: 1
    • important implication and pathogenesis important implication: 1, 2