Author: Zheng, Jie; Tan, Boon Huan; Sugrue, Richard; Tang, Kai
Title: Current Approaches on Viral Infection: Proteomics and Functional Validations Document date: 2012_11_16
ID: 1grbdlib_1
Snippet: Invasive viruses are adaptively infectious and pathogenic. Although host cells evolve and occupy a network of multiple defensive measures, microbial pathogens could in turn manipulate cellular machinery to counteract those immune defenses in order to evade or neutralize them (Finlay and McFadden, 2006) . This might be in part attributed to the fact that viruses evolve and mutate much more quickly than their hosts, and result in emerging mutants w.....
Document: Invasive viruses are adaptively infectious and pathogenic. Although host cells evolve and occupy a network of multiple defensive measures, microbial pathogens could in turn manipulate cellular machinery to counteract those immune defenses in order to evade or neutralize them (Finlay and McFadden, 2006) . This might be in part attributed to the fact that viruses evolve and mutate much more quickly than their hosts, and result in emerging mutants with enhanced viral attacks. For instance, viral genomes of RNA viruses, e.g., influenza A virus, intrinsically exhibit hypervariations and continued mutations due to a lack of proofreading RNA dependent RNA polymerases (Holland et al., 1982) . This may also be derived from the diversity of virus families and a vast number of formidable viruses threatening mankind; for examples, the representatives are human immunodeficiency virus, influenza virus, respiratory syncytial virus (RSV), severe acute respiratory syndrome (SARS), dengue virus, and so on. Epidemic or even pandemic diseases occurred in recent years upon breakout of those infectious viruses.
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