Author: Shrestha, Ashish C.; Wijesundara, Danushka K.; Masavuli, Makutiro G.; Mekonnen, Zelalem A.; Gowans, Eric J.; Grubor-Bauk, Branka
Title: Cytolytic Perforin as an Adjuvant to Enhance the Immunogenicity of DNA Vaccines Document date: 2019_4_30
ID: 141u6ax7_18
Snippet: lytic DNA vaccines are based on a bicistronic DNA plasmid constructed on a pVax (Invitrogen) with a Cytomegalovirus (CMV) promoter and a Simian Virus (SV40) promoter gene encoding the protein of interest as an immunogen is inserted downstream of the CMV and the gene encoding a truncated version of mouse PRF downstream of the SV40 promoter . The SV40 is a weaker promoter compared to CMV and has been shown to result in 10-fold tein expression in tr.....
Document: lytic DNA vaccines are based on a bicistronic DNA plasmid constructed on a pVax (Invitrogen) with a Cytomegalovirus (CMV) promoter and a Simian Virus (SV40) promoter gene encoding the protein of interest as an immunogen is inserted downstream of the CMV and the gene encoding a truncated version of mouse PRF downstream of the SV40 promoter . The SV40 is a weaker promoter compared to CMV and has been shown to result in 10-fold tein expression in transfected HEK293T cells in vitro [55, 95] .
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