Author: Shrestha, Ashish C.; Wijesundara, Danushka K.; Masavuli, Makutiro G.; Mekonnen, Zelalem A.; Gowans, Eric J.; Grubor-Bauk, Branka
Title: Cytolytic Perforin as an Adjuvant to Enhance the Immunogenicity of DNA Vaccines Document date: 2019_4_30
ID: 141u6ax7_2
Snippet: DNA vaccines can overcome some of these challenges, as it is relatively easy to produce large number of doses within a short period of time, and they are stable at ambient temperature and do not require cold chain transportation. They are also consistent between lots and have an excellent safety profile allowing for safety evaluations by regulatory authorities and distribution in a large scale [6, 7] . Importantly, DNA vaccines can induce both hu.....
Document: DNA vaccines can overcome some of these challenges, as it is relatively easy to produce large number of doses within a short period of time, and they are stable at ambient temperature and do not require cold chain transportation. They are also consistent between lots and have an excellent safety profile allowing for safety evaluations by regulatory authorities and distribution in a large scale [6, 7] . Importantly, DNA vaccines can induce both humoral and cell-mediated responses in the vaccinated host [8] [9] [10] . Although they are safe and well tolerated, they are often poorly immunogenic and inefficacious in humans [11] . Therefore, recent studies on the advancements of DNA vaccines are focused on effective delivery and increasing the immunogenicity of the encoded antigen/s of interest [12, 13] .
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