Selected article for: "cdna complementary dna and complementary dna"
Author: Hayward, Joshua A; Tachedjian, Mary; Cui, Jie; Cheng, Adam Z; Johnson, Adam; Baker, Michelle L; Harris, Reuben S; Wang, Lin-Fa; Tachedjian, Gilda
Title: Differential Evolution of Antiretroviral Restriction Factors in Pteropid Bats as Revealed by APOBEC3 Gene Complexity
  • Document date: 2018_3_29
    • ID: 1i6c0l3e_6
    Snippet: Pteropid Bats Express a Diverse Range of APOBEC3 Gene Products Pteropid A3 gene expression was initially determined by searching for A3 homologues in the P. alecto transcriptome database through a tBLASTn analysis using the human A3 proteins A3A, A3C, and A3H, representing the three zinccoordinating cytosine deaminase motif (Z-domain) subtypes A3Z1, A3Z2, and A3Z3, as search queries. A3 expression was subsequently assessed through analysis of cDN.....
    Document: Pteropid Bats Express a Diverse Range of APOBEC3 Gene Products Pteropid A3 gene expression was initially determined by searching for A3 homologues in the P. alecto transcriptome database through a tBLASTn analysis using the human A3 proteins A3A, A3C, and A3H, representing the three zinccoordinating cytosine deaminase motif (Z-domain) subtypes A3Z1, A3Z2, and A3Z3, as search queries. A3 expression was subsequently assessed through analysis of cDNA (complementary DNA) generated from P. alecto spleen tissue, which harbors multiple immune cell types known to express A3 genes in humans (Refsland et al. 2010 ). This analysis revealed 20 distinct A3 mRNA transcripts derived from seven A3Z1 genes, five A3Z2 genes, and a single A3Z3 gene (supplementary table S1, Supplementary Material online). Pairwise comparison of these A3 transcripts (supplementary fig. S1 , Supplementary Material online) reveal a wide range of sequence identities between pteropid A3 genes, indicating considerable diversity among homologs: A3Z1 genes range from 86% to 97% identity, whereas A3Z2 genes range from 54% to 99% identity.

    Search related documents:
    Co phrase search for related documents
    • alecto spleen tissue and spleen tissue: 1, 2, 3
    • cell type and considerable diversity: 1
    • cell type and diverse range: 1
    • cell type and gene expression: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • cell type and sequence identity: 1, 2, 3, 4
    • cell type and spleen tissue: 1, 2
    • cell type and supplementary table: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
    • cell type and transcriptome database: 1
    • cell type and wide range: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • cytosine deaminase and gene expression: 1
    • diverse range and gene expression: 1, 2, 3
    • diverse range and spleen tissue: 1
    • diverse range and supplementary table: 1
    • diverse range and wide range: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • gene expression and sequence identity: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13
    • gene expression and spleen tissue: 1, 2, 3, 4, 5
    • gene expression and supplementary table: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18
    • gene expression and transcriptome database: 1, 2, 3
    • gene expression and wide range: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25