Author: Chiramel, Abhilash I.; Brady, Nathan R.; Bartenschlager, Ralf
Title: Divergent Roles of Autophagy in Virus Infection Document date: 2013_1_25
ID: 1oawya1p_39
Snippet: Apart from a direct contribution to the formation of membranous replication factories, autophagy can promote viral replication in other ways. For instance, a recent study by Heaton and co-workers identified a novel proviral mechanism of autophagy: the production of energy [87] . Taking into account the so-called lipophagy, i.e., the degradation of triglycerides stored in lipid droplets (LDs), the authors demonstrated that DENV infection of hepato.....
Document: Apart from a direct contribution to the formation of membranous replication factories, autophagy can promote viral replication in other ways. For instance, a recent study by Heaton and co-workers identified a novel proviral mechanism of autophagy: the production of energy [87] . Taking into account the so-called lipophagy, i.e., the degradation of triglycerides stored in lipid droplets (LDs), the authors demonstrated that DENV infection of hepatocytes induces autophagy-mediated LD degradation. This results in a mobilization of triglycerides that are used -oxidation. The signaling pathway controlling the selective degradation of LDs via autophagy and the mechanism that regulates ATP production are not clear. Nevertheless, this study is the first to link of viral infection to autophagy-dependent regulation of lipid metabolism. It will be interesting to determine whether this link is unique to DENV or applies to other (LD-dependent) viruses.
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