Selected article for: "hybrid screening and yeast hybrid screening"
Author: Chiramel, Abhilash I.; Brady, Nathan R.; Bartenschlager, Ralf
Title: Divergent Roles of Autophagy in Virus Infection
  • Document date: 2013_1_25
    • ID: 1oawya1p_46
    Snippet: A recent report by Gre´goire et al. showed that the IRGM protein (immunity-associated GTPase family M) is a common target of several RNA viruses to subvert the autophagy network [91] . By using a yeast two-hybrid screening approach and bioinformatic analyses. the authors determined the ability of 83 proteins from different RNA virus families to interact with 44 human autophagy-associated proteins. It turned out that the autophagy network is high.....
    Document: A recent report by Gre´goire et al. showed that the IRGM protein (immunity-associated GTPase family M) is a common target of several RNA viruses to subvert the autophagy network [91] . By using a yeast two-hybrid screening approach and bioinformatic analyses. the authors determined the ability of 83 proteins from different RNA virus families to interact with 44 human autophagy-associated proteins. It turned out that the autophagy network is highly targeted by RNA viruses. Importantly, IRGM, the most frequently targeted protein, interacted with the autophagy proteins Atg5, Atg10, MAP1CL3C and SH3GLB1 (SH3-domain GRB2-like endophilin B1). Silencing of IRGM expression impaired both Measles virus (MeV), HCV and HIV-1 induced autophagy and virion production. Furthermore, IRGM interacted with MeV capsid, HCV NS3 and HIV Nef. These interactions were sufficient to induce autophagy via an IRGM-dependent pathway. This work revealed a primary role of IRGM in virusinduced autophagy and identified a large range of RNA viruses that use common strategies to manipulate autophagy in order to promote viral replication [91] .

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