Author: Malik, Shahana S.; Azem-e-Zahra, Syeda; Kim, Kyung Mo; Caetano-Anollés, Gustavo; Nasir, Arshan
Title: Do Viruses Exchange Genes across Superkingdoms of Life? Document date: 2017_10_31
ID: 12dee0lv_27
Snippet: Fourth, we raise the issue of coverage of viral proteomes, where coverage is defined by the number of viral genes (proteins) with significant homologs in either sequence or structure databases. We have previously shown that roughly >60% of viral proteins did not match to known FSFs ( Figure 2B in Nasir and Caetano-Anollés, 2015) . It is already well-known that the majority of viral genes lack sequence homologies, putatively termed ORFans (Ogata .....
Document: Fourth, we raise the issue of coverage of viral proteomes, where coverage is defined by the number of viral genes (proteins) with significant homologs in either sequence or structure databases. We have previously shown that roughly >60% of viral proteins did not match to known FSFs ( Figure 2B in Nasir and Caetano-Anollés, 2015) . It is already well-known that the majority of viral genes lack sequence homologies, putatively termed ORFans (Ogata and Claverie, 2007; Yin and Fischer, 2008; Cortez et al., 2009) . These viral genes either evolved fast and hence are no longer recognizable at either sequence or structure levels, or represent genes that originated directly in viruses (Forterre, 2011 ) (e.g., VSFs in Table 2 ). Determining the origin of viral ORFans remains an open and important question in virology research.
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