Do Viruses Exchange Genes across Superkingdoms of Life?

Malik, Shahana S.; Azem-e-Zahra, Syeda; Kim, Kyung Mo; Caetano-Anollés, Gustavo; Nasir, Arshan

Exclusively between Viruses and Their Host Genomes Were Likely Transferred from Viruses to Cells A total of 98, 441, and 489 FSFs were detected in the proteomes of 62 archaeoviruses, 1,223 bacterioviruses, and 2,155 eukaryoviruses (Table S1), respectively (Figure 2) . Based on the presence/absence of these viral FSFs in 1,620 cellular proteomes from Archaea (122 in number), Bacteria (1,115), and Eukarya (383), seven mutually exclusive Venn groups could be defined each for archaeoviruses, bacterioviruses, and eukaryoviruses: A (viral FSFs shared only with archaeal proteomes), B (shared only with bacterial proteomes), E (shared only with eukaryotic proteomes), AB (shared only with prokaryotic proteomes), AE (shared only with archaeal and eukaryal proteomes), BE (shared only with bacterial and eukaryal proteomes), and ABE (shared with proteomes of all three superkingdoms), in addition to virusspecific (V) FSFs not detected in cellular proteomes (Figure 2) .