Author: Xing, Yang; Liqi, Zhu; Jian, Lin; Qinghua, Yu; Qian, Yang
Title: Doxycycline Induces Mitophagy and Suppresses Production of Interferon-ß in IPEC-J2 Cells Document date: 2017_2_1
ID: 1ljye9pj_1
Snippet: Intestinal epithelial cells, which were originally called "mitochondria-rich" cells, are important for absorbing nutrition and mediating the immune response (Brown and Breton, 1996) . Moreover, mitochondria play an important role with regard to reactive oxygen species (ROS), inducing programmed cell death and transducing stress and metabolic signals (Albers and Beal, 2000; Galluzzi et al., 2012) . Therefore, mitochondrial biogenesis is tightly re.....
Document: Intestinal epithelial cells, which were originally called "mitochondria-rich" cells, are important for absorbing nutrition and mediating the immune response (Brown and Breton, 1996) . Moreover, mitochondria play an important role with regard to reactive oxygen species (ROS), inducing programmed cell death and transducing stress and metabolic signals (Albers and Beal, 2000; Galluzzi et al., 2012) . Therefore, mitochondrial biogenesis is tightly regulated to maintain overall cellular homeostasis (Wai and Langer, 2016) . A variety of pathogens and chemicals can affect the mitochondrial dynamics of intestinal epithelial cells and destroy cell homeostasis (Novak and Mollen, 2015) .
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