Author: Xing, Yang; Liqi, Zhu; Jian, Lin; Qinghua, Yu; Qian, Yang
Title: Doxycycline Induces Mitophagy and Suppresses Production of Interferon-ß in IPEC-J2 Cells Document date: 2017_2_1
ID: 1ljye9pj_43
Snippet: The important role of mitochondria in the intrinsic apoptosis pathway led us to postulate that DOX might induce mitophagy in IPEC-J2 cells to inhibit apoptosis by removing damaged mitochondria. Indeed, mitophagy induced by a TGEV infection counteracts apoptosis in IPEC-J2 cells, and inhibiting autophagy enhances apoptosis in Hela cells infected with MV-Edm (Richetta et al., 2013) . A few viruses suppress apoptosis by mitophagy during an infection.....
Document: The important role of mitochondria in the intrinsic apoptosis pathway led us to postulate that DOX might induce mitophagy in IPEC-J2 cells to inhibit apoptosis by removing damaged mitochondria. Indeed, mitophagy induced by a TGEV infection counteracts apoptosis in IPEC-J2 cells, and inhibiting autophagy enhances apoptosis in Hela cells infected with MV-Edm (Richetta et al., 2013) . A few viruses suppress apoptosis by mitophagy during an infection (Kim et al., 2013a (Kim et al., ,b, 2014 Meng et al., 2014) . Our experimental results first indicate that DOX could induce complete mitophagy in IPEC-J2 cells (Figure 4) .
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