Author: Xing, Yang; Liqi, Zhu; Jian, Lin; Qinghua, Yu; Qian, Yang
Title: Doxycycline Induces Mitophagy and Suppresses Production of Interferon-ß in IPEC-J2 Cells Document date: 2017_2_1
ID: 1ljye9pj_44
Snippet: Mitochondrial dynamics regulate antiviral innate immunity (Castanier et al., 2010) . Replication of hepatitis C virus (HCV) increases in response to Parkin-mediated mitophagy (Kim et al., 2013a) , and HBV favors its own replication by promoting bulk autophagy (Tang et al., 2009; Sir et al., 2010; Li et al., 2011) . The late stages of mitophagy must be completed to attenuate RLR signaling . Our data suggest that DOX decreased IFN-β production in .....
Document: Mitochondrial dynamics regulate antiviral innate immunity (Castanier et al., 2010) . Replication of hepatitis C virus (HCV) increases in response to Parkin-mediated mitophagy (Kim et al., 2013a) , and HBV favors its own replication by promoting bulk autophagy (Tang et al., 2009; Sir et al., 2010; Li et al., 2011) . The late stages of mitophagy must be completed to attenuate RLR signaling . Our data suggest that DOX decreased IFN-β production in IPEC-J2 cells transfected with poly (I: C) (Figure 5) . As a result, DOX promoted replication of TGEV, which is a single-stranded RNA virus (Figure 6) . We also provide evidence for the effects of DOX on IPEC-J2 cells. DOX induced mitophagy to mitigate the antiviral innate immune response, which might contribute to the replication of TGEV in intestinal epithelial cells. These results suggest caution to prevent the abuse of DOX in pig husbandry.
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