Selected article for: "airway hyper responsiveness and hyper responsiveness"
Author: Leaker, Brian R.; Singh, Dave; Lindgren, Sam; Almqvist, Gun; Eriksson, Leif; Young, Barbara; O’Connor, Brian
Title: Effects of the Toll-like receptor 7 (TLR7) agonist, AZD8848, on allergen-induced responses in patients with mild asthma: a double-blind, randomised, parallel-group study
  • Document date: 2019_12_19
    • ID: 15e043uf_2
    Snippet: Allergic asthma is a chronic inflammatory disorder of the airways characterised by eosinophil infiltration, airway hyper-responsiveness (AHR) and excessive airway mucus production [7, 8] . Th2 cells respond to environmental antigens by secreting a range of cytokines, including interleukin (IL)-4, IL-5, IL-9 and IL-13 [7] . Such responses can be suppressed by T reg cells through the secretion of the anti-inflammatory cytokine IL-10 [9] and type II.....
    Document: Allergic asthma is a chronic inflammatory disorder of the airways characterised by eosinophil infiltration, airway hyper-responsiveness (AHR) and excessive airway mucus production [7, 8] . Th2 cells respond to environmental antigens by secreting a range of cytokines, including interleukin (IL)-4, IL-5, IL-9 and IL-13 [7] . Such responses can be suppressed by T reg cells through the secretion of the anti-inflammatory cytokine IL-10 [9] and type II interferon gamma (IFNγ) secreted by Th1 cells [10] .

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