Author: Leaker, Brian R.; Singh, Dave; Lindgren, Sam; Almqvist, Gun; Eriksson, Leif; Young, Barbara; O’Connor, Brian
Title: Effects of the Toll-like receptor 7 (TLR7) agonist, AZD8848, on allergen-induced responses in patients with mild asthma: a double-blind, randomised, parallel-group study Document date: 2019_12_19
ID: 15e043uf_46
Snippet: AZD8848 is a metabolically labile ester with a plasma half-life (t ½ ) of 2-3 min, which is rapidly converted to a weakly active metabolite in the plasma with a t ½ of 36 min [35] . The hypothesis is that there would be minimal systemic exposure and limited IFN I immune activation due to this brief half-life, resulting in a reduced incidence of side effects. In this study the drug was administered locally to the nose, avoiding inhalation to the.....
Document: AZD8848 is a metabolically labile ester with a plasma half-life (t ½ ) of 2-3 min, which is rapidly converted to a weakly active metabolite in the plasma with a t ½ of 36 min [35] . The hypothesis is that there would be minimal systemic exposure and limited IFN I immune activation due to this brief half-life, resulting in a reduced incidence of side effects. In this study the drug was administered locally to the nose, avoiding inhalation to the lung, but with therapeutic effects observed in the lung and minimal systemic exposure.
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