Author: Meng, Fandan; Wu, Nai-Huei; Seitz, Maren; Herrler, Georg; Valentin-Weigand, Peter
Title: Efficient suilysin-mediated invasion and apoptosis in porcine respiratory epithelial cells after streptococcal infection under air-liquid interface conditions Document date: 2016_5_27
ID: 0jsc81sy_21
Snippet: Adherence to and colonization of host cells is important for S. suis to cause infection and initiate disease 40, 41 . Although the respiratory epithelium is the main target tissue of respiratory pathogens, the role of the well-differentiated airway epithelial cells for bacterial infection has been poorly studied 21 . Here we show that suilysin promotes the adherence to and invasion of ALI cultures of porcine airway epithelial cells by encapsulate.....
Document: Adherence to and colonization of host cells is important for S. suis to cause infection and initiate disease 40, 41 . Although the respiratory epithelium is the main target tissue of respiratory pathogens, the role of the well-differentiated airway epithelial cells for bacterial infection has been poorly studied 21 . Here we show that suilysin promotes the adherence to and invasion of ALI cultures of porcine airway epithelial cells by encapsulated and nonencapsulated S. suis, which is consistent with a previous study using immortalized cells 39 . Ciliated cells were found to be the primary target cells for S. suis adherence.
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