Selected article for: "absence presence and active site"
Author: Natalia Fintelman-Rodrigues; Carolina Q. Sacramento; Carlyle Ribeiro Lima; Franklin Souza da Silva; André C. Ferreira; Mayara Mattos; Caroline S. de Freitas; Vinicius Cardoso Soares; Suelen da Silva Gomes Dias; Jairo R. Temerozo; Milene Miranda; Aline R. Matos; Fernando A. Bozza; Nicolas Carels; Carlos Roberto Alves; Marilda M. Siqueira; Patrícia T. Bozza; Thiago Moreno L. Souza
Title: Atazanavir inhibits SARS-CoV-2 replication and pro-inflammatory cytokine production
  • Document date: 2020_4_5
    • ID: 6zk0ioep_51
    Snippet: Experimental Legend for the Figures Figure 1 . The active site of SARS-CoV-2 Mpro in the absence and presence of the inhibitors. A representative structure of Mpro (PDB:6LU7) was color coded to show the electrostatic potential of residues in the active site for negative (blue) and positive (red) charges. Panel A, the cavities of ligand interaction designated S1*, S1 and S2 in the absence of inhibitors. Panel B, placement of LPV (cyan) docked in.....
    Document: Experimental Legend for the Figures Figure 1 . The active site of SARS-CoV-2 Mpro in the absence and presence of the inhibitors. A representative structure of Mpro (PDB:6LU7) was color coded to show the electrostatic potential of residues in the active site for negative (blue) and positive (red) charges. Panel A, the cavities of ligand interaction designated S1*, S1 and S2 in the absence of inhibitors. Panel B, placement of LPV (cyan) docked in the S1* and S2 regions of the active site. Panel C, placement of ATV (orange) docked in the S1* and S1 regions of the active site. The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.04.020925 doi: bioRxiv preprint

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