Author: Kun Sun; Liuqi Gu; Li Ma; Yunfeng Duan
Title: Atlas of ACE2 gene expression in mammals reveals novel insights in transmission of SARS-Cov-2 Document date: 2020_3_31
ID: 89sg0cpk_22
Snippet: We also collected transcriptome data from tissues that were not in the GTEx datasets, including cornea, epidermal keratinocytes, and lung fibroblasts. These tissues are frequently exposed to the air. ACE2 gene was expressed in corneal epithelial cells ( Figure 2B) , suggesting that the eye could be vulnerable to SARS-CoV-2 infections. In contrast, ACE2 was not expressed in epidermal keratinocytes nor lung fibroblasts, which was consistent with th.....
Document: We also collected transcriptome data from tissues that were not in the GTEx datasets, including cornea, epidermal keratinocytes, and lung fibroblasts. These tissues are frequently exposed to the air. ACE2 gene was expressed in corneal epithelial cells ( Figure 2B) , suggesting that the eye could be vulnerable to SARS-CoV-2 infections. In contrast, ACE2 was not expressed in epidermal keratinocytes nor lung fibroblasts, which was consistent with the above analysis based on GTEx data. This result was also consistent with a previous report based on single-cell RNA-seq data that ACE2 was only expressed in the alveolar type 2 (AT2) cells in lungs 35 .
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