Author: Lindqvist, Richard; Mundt, Filip; Gilthorpe, Jonathan D.; Wölfel, Silke; Gekara, Nelson O.; Kröger, Andrea; Överby, Anna K.
Title: Fast type I interferon response protects astrocytes from flavivirus infection and virus-induced cytopathic effects Document date: 2016_10_24
ID: 09tcnsxv_4
Snippet: We found that astrocytes respond very quickly after viral infection by upregulation of type I IFNs. This upregulation restricts virus replication and spread in primary cultures and contributes to cell survival. By RNA sequencing (RNASeq), we could show that uninfected astrocytes exist in an active antiviral state, which enables fast recognition and response to viral infection by upregulating important antiviral ISGs and that this antiviral state .....
Document: We found that astrocytes respond very quickly after viral infection by upregulation of type I IFNs. This upregulation restricts virus replication and spread in primary cultures and contributes to cell survival. By RNA sequencing (RNASeq), we could show that uninfected astrocytes exist in an active antiviral state, which enables fast recognition and response to viral infection by upregulating important antiviral ISGs and that this antiviral state is dependent on IFNAR expression.
Search related documents:
Co phrase search for related documents- antiviral isg and IFNAR expression: 1
- antiviral isg and primary culture: 1
- antiviral isg and quickly respond: 1
- antiviral isg and rna sequencing: 1, 2, 3
- antiviral isg and viral infection: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14
- antiviral isg and viral infection response: 1
- antiviral isg and virus replication: 1, 2, 3, 4, 5, 6, 7, 8
- antiviral state and cell survival: 1, 2, 3
- antiviral state and ifn type: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54
- antiviral state and ifn type upregulation: 1
- antiviral state and IFNAR expression: 1
- antiviral state and important antiviral isg: 1
- antiviral state and quickly respond: 1
- antiviral state and rna sequencing: 1, 2, 3, 4, 5
- antiviral state and viral infection: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48
- antiviral state and viral infection response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
- antiviral state and virus replication: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
- antiviral state and virus replication restrict: 1
- cell survival and ifn type: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14
Co phrase search for related documents, hyperlinks ordered by date