Author: Lindqvist, Richard; Mundt, Filip; Gilthorpe, Jonathan D.; Wölfel, Silke; Gekara, Nelson O.; Kröger, Andrea; Överby, Anna K.
Title: Fast type I interferon response protects astrocytes from flavivirus infection and virus-induced cytopathic effects Document date: 2016_10_24
ID: 09tcnsxv_46
Snippet: With this comprehensive bioinformatics analysis, we can show that the main gene sets enriched after supernatant treatment are IFN signaling gene sets very similar to the IFNαB/D treatment (Fig. 6) , overall indicating that IFNs are the main response induced after infection. We show that IFNAR −/− astrocytes not only express lower levels of key antiviral ISGs (Fig. 5 ) but also express lower levels of ISGs, PRRs, innate immune signaling, and .....
Document: With this comprehensive bioinformatics analysis, we can show that the main gene sets enriched after supernatant treatment are IFN signaling gene sets very similar to the IFNαB/D treatment (Fig. 6) , overall indicating that IFNs are the main response induced after infection. We show that IFNAR −/− astrocytes not only express lower levels of key antiviral ISGs (Fig. 5 ) but also express lower levels of ISGs, PRRs, innate immune signaling, and transcription factors generally (Fig. 4d and Additional file 1: Table S2 ), which probably contributes to the susceptibility of these cells (Figs. 1 and 2) .
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