Author: Brauburger, Kristina; Hume, Adam J.; Mühlberger, Elke; Olejnik, Judith
Title: Forty-Five Years of Marburg Virus Research Document date: 2012_10_1
ID: 0hlj6r10_56
Snippet: The role of MARV VP30 in viral transcription and replication is not well understood. In contrast to EBOV VP30, which plays an important role in regulating transcription initiation [68, 143, [155] [156] [157] , MARV VP30 is not essential for transcription or replication activity in a MARV minigenome system [113, 134] . Nevertheless, it seems to play an important role in viral amplification, since rescue of a full-length MARV clone is only successf.....
Document: The role of MARV VP30 in viral transcription and replication is not well understood. In contrast to EBOV VP30, which plays an important role in regulating transcription initiation [68, 143, [155] [156] [157] , MARV VP30 is not essential for transcription or replication activity in a MARV minigenome system [113, 134] . Nevertheless, it seems to play an important role in viral amplification, since rescue of a full-length MARV clone is only successful in the presence of VP30 [158] . In addition, down-regulation of VP30 by RNA interference in MARV-infected cells led to the reduction of both viral protein synthesis and virion production [159] . Among the NNS RNA viruses, only the members of the subfamily Pneumovirinae possess a protein similar to VP30, M2-1, which functions as a transcription processivity factor [160] .
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