Author: Mazumder, Tarikul Huda; Chakraborty, Supriyo
Title: Gaining Insights into the Codon Usage Patterns of TP53 Gene across Eight Mammalian Species Document date: 2015_3_25
ID: 1qtqergw_1
Snippet: TP53 gene encodes tumor protein p53 which is known as the "guardian of the genome" as it plays a vital role in maintaining genomic stability by preventing mutation in the genome [1] . The p53 primarily acts as transcription factor and stands out as a key player in restricting tumor cell invasion that includes the ability to induce cell cycle arrest, DNA repair, senescence and apoptosis [2] . Mutation in p53 results in abnormal proliferation of ce.....
Document: TP53 gene encodes tumor protein p53 which is known as the "guardian of the genome" as it plays a vital role in maintaining genomic stability by preventing mutation in the genome [1] . The p53 primarily acts as transcription factor and stands out as a key player in restricting tumor cell invasion that includes the ability to induce cell cycle arrest, DNA repair, senescence and apoptosis [2] . Mutation in p53 results in abnormal proliferation of cells that leads to the formation of tumor development and so TP53 gene is cataloged as tumor suppressor gene [3] .
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