Author: Bloom, Kristie; Maepa, Mohube Betty; Ely, Abdullah; Arbuthnot, Patrick
Title: Gene Therapy for Chronic HBV—Can We Eliminate cccDNA? Document date: 2018_4_12
ID: 0dr9eans_17
Snippet: Administration of recombinant IFN-α or its pegylated derivatives remains the only immunomodulatory drugs licensed for management of chronic HBV infection. IFN-α is therefore the only licensed anti-HBV therapy capable of eliminating cccDNA. Immunomodulation has been shown to augment innate and adaptive immune responses against the virus. Stimulating T-cell-mediated elimination of infected hepatocytes, and indirectly cccDNA, is thus a promising i.....
Document: Administration of recombinant IFN-α or its pegylated derivatives remains the only immunomodulatory drugs licensed for management of chronic HBV infection. IFN-α is therefore the only licensed anti-HBV therapy capable of eliminating cccDNA. Immunomodulation has been shown to augment innate and adaptive immune responses against the virus. Stimulating T-cell-mediated elimination of infected hepatocytes, and indirectly cccDNA, is thus a promising immune-based strategy to achieve functional cure from HBV infection. However, the success rate of IFN therapy remains low and side effects represent a major shortcoming of this therapy. Gene therapy to enable durable expression of immune modulators may be useful to attenuate cccDNA.
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