Author: Bloom, Kristie; Maepa, Mohube Betty; Ely, Abdullah; Arbuthnot, Patrick
Title: Gene Therapy for Chronic HBV—Can We Eliminate cccDNA? Document date: 2018_4_12
ID: 0dr9eans_17
Snippet: Administration of recombinant IFN-α or its pegylated derivatives remains the only immunomodulatory drugs licensed for management of chronic HBV infection. IFN-α is therefore the only licensed anti-HBV therapy capable of eliminating cccDNA. Immunomodulation has been shown to augment innate and adaptive immune responses against the virus. Stimulating T-cell-mediated elimination of infected hepatocytes, and indirectly cccDNA, is thus a promising i.....
Document: Administration of recombinant IFN-α or its pegylated derivatives remains the only immunomodulatory drugs licensed for management of chronic HBV infection. IFN-α is therefore the only licensed anti-HBV therapy capable of eliminating cccDNA. Immunomodulation has been shown to augment innate and adaptive immune responses against the virus. Stimulating T-cell-mediated elimination of infected hepatocytes, and indirectly cccDNA, is thus a promising immune-based strategy to achieve functional cure from HBV infection. However, the success rate of IFN therapy remains low and side effects represent a major shortcoming of this therapy. Gene therapy to enable durable expression of immune modulators may be useful to attenuate cccDNA.
Search related documents:
Co phrase search for related documents- anti hbv therapy and chronic HBV infection: 1
- anti hbv therapy and gene therapy: 1
- anti hbv therapy and HBV infection: 1, 2, 3, 4
- anti hbv therapy and IFN therapy: 1
- cccdna eliminate and chronic HBV infection: 1
- cccdna eliminate and gene therapy: 1
- cccdna eliminate and HBV infection: 1
- cell mediate and gene therapy: 1
- chronic HBV infection and functional cure: 1
- chronic HBV infection and functional cure achieve: 1
- chronic HBV infection and gene therapy: 1, 2, 3, 4, 5, 6
- chronic HBV infection and HBV infection: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- chronic HBV infection and IFN therapy: 1
- chronic HBV infection management and HBV infection: 1
- functional cure achieve and HBV infection: 1
- functional cure achieve and IFN therapy: 1
- functional cure and gene therapy: 1, 2, 3
- functional cure and HBV infection: 1, 2
- functional cure and IFN therapy: 1
Co phrase search for related documents, hyperlinks ordered by date