Author: Zheng, Yueming; Zhu, Xuejing; Zhou, Pingzheng; Lan, Xi; Xu, Haiyan; Li, Min; Gao, Zhaobing
Title: Hexachlorophene Is a Potent KCNQ1/KCNE1 Potassium Channel Activator Which Rescues LQTs Mutants Document date: 2012_12_12
ID: 1manzf3l_12
Snippet: Patch clamp data were processed using Clampfit 10.2 (Molecular Devices, Sunnyvale, CA) and then analyzed in GraphPad Prism 5 (GraphPad Software, San Diego, CA). Voltage-dependent activation curves were fitted with the Boltzmann equation, G = G min +(G max -G min )/(1+exp(V-V 1/2 )/S), where G max is the maximum conductance, G min is the minimum conductance, V 1/2 is the voltage for reaching 50% of maximum conductance, and S is the slope factor. D.....
Document: Patch clamp data were processed using Clampfit 10.2 (Molecular Devices, Sunnyvale, CA) and then analyzed in GraphPad Prism 5 (GraphPad Software, San Diego, CA). Voltage-dependent activation curves were fitted with the Boltzmann equation, G = G min +(G max -G min )/(1+exp(V-V 1/2 )/S), where G max is the maximum conductance, G min is the minimum conductance, V 1/2 is the voltage for reaching 50% of maximum conductance, and S is the slope factor. Dose-response curves were fitted with the Hill equation, E = E max /(1-(EC 50 /C)P), where EC 50 is the drug concentration producing half of the maximum response, and P is the Hill coefficient. Data are presented as means 6 SD. Significance was estimated using unpaired two-tailed Student's t tests. An effect was considered significant if p,0.05.
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